分布于西藏地区的鼠尾草属植物化学成分研究进展Advances on chemical constituents of Tibetan Salvia genus
符佳,杨龙飞,梁峻铭,徐玲,赵刚,付强
FU Jia,YANG Long-fei,LIANG Jun-ming,XU Ling,ZHAO Gang,FU Qiang
摘要(Abstract):
鼠尾草属Salvia是唇形科中最大的一属,全世界约有1 000余种。我国鼠尾草属植物资源丰富,分布于全国各地,尤以西南为最多。该属植物含有多种类型的化学成分,主要类型有倍半萜类、二萜类、三萜类和酚性类化合物等。为了更好的开发利用西藏地区鼠尾草属植物,该文将对分布于西藏地区鼠尾草属植物的化学成分进行综述。
Salvia is the largest genus of Labiatae family,and there are more than 1 000 species around the world. Our country is rich in the resources of Salvia plants. The plants of this genus contain multiple chemical components,including sesquiterpenoids,diterpenoids,triterpenoids and phenols,et al. In order to develop better Tibetan plants of Salvia genus,this article reviewed and summarized the constituents from Tibetan Salvia genus.
关键词(KeyWords):
西藏;鼠尾草属;化学成分
Tibet;Salvia;chemical constituents
基金项目(Foundation): 成都大学特聘研究员科研基金项目(2081915021)
作者(Author):
符佳,杨龙飞,梁峻铭,徐玲,赵刚,付强
FU Jia,YANG Long-fei,LIANG Jun-ming,XU Ling,ZHAO Gang,FU Qiang
DOI: 10.19540/j.cnki.cjcmm.20170807.005
参考文献(References):
- [1]中国科学院中国植物志编委会.中国植物志.66卷[M].北京:科学出版社,1977:192.
- [2]Wu Y B,Ni Z Y,Shi Q W,et al.Constituents from Salvia species and their biological activities[J].Chem Rev,2012,112(11):5967.
- [3]张宝宝,聂诗琪,梁敬钰,等.鼠尾草属植物的化学成分及药理活性研究进展[J].海峡药学,2014,26(11):1.
- [4]彭勍,刘建勋.鼠尾草属植物化学成分及生物活性研究的新进展[J].中国中药杂志,2015,40(11):2096.
- [5]Jassbi A R,Zare S,Firuzi O,et al.Bioactive phytochemicals from shoots and roots of Salvia species[J].Phytochemistry,2016,15:289.
- [6]中国科学院青藏高原综合科学考察队.西藏植物志.4卷[M].北京:科学出版社,1983:179.
- [7]Hazn edaroglu M Z,Karab ay N U,Zeybek U.An tibacterial activity of Salvia tomentosa essential oil[J].Fitoterapia,2001,72(7):9.
- [8]Hanes K R.Antidepres sant effects of the herb Salvia divinorum:a case report[J].J Clin Psychopharmacol,2001,21(6):634.
- [9]Li Y,Wu Y Q,Du X,et al.Germacrane sesquiterpene Esters from Salvia roborowskii[J].Planta Med,2003,69(8):782.
- [10]Liu Y,Li C,Shi J G,et al.Two new sesquiterpenes from Salvia roborowskii Maxim.[J].Helv Chim Acta,2009,92(2):335.
- [11]Xu G,Peng L Y,Li X L,et al.New sesquiterpenoids from Salvia castanea Diels f.tomentosa[J].Helv Chim Acta,2005,88(8):2370.
- [12]Xu G,Peng L Y,Hou A J,et al.Isolation,structural elucidation,and chemical transformation of interconvertible 8,12-hemiketal germacranolide sesquiterpenoids from Salvia castanea Diels f.tomentosa Stib[J].Tetrahedron,2008,64(40):9490.
- [13]Dai Y Q,Liu L,Xie G Y,et al.Four new eudesmane-type sesquiterpenes from the basal leaves of Salvia plebeia R.Br[J].Fitoterapia,2014,94:142.
- [14]Jang H J,Oh H M,Hwang J T,et al.Eudesmane-type sesquiterpenoids from Salvia plebeia inhibit IL-6-induced STAT3 activation[J].Phytochemistry,2016,130:335.
- [15]Xu G,Peng L Y,Shen X L,et al.Interconvertible eudesmanolides containing a 6,12-hemiketal function from Salvia castanea Diels f.tomentosa Stib[J].Helv Chim Acta,2010,93(9):1773.
- [16]Cao S Y,Ke Z L,Xi L M.A new sesquiterpene lactone from Salvia plebeian[J].J Asian Nat Prod Res,2013,15(4):4047.
- [17]Miura K,Kikuzaki H,Nakatani N.Antioxidant activity of chemical components from sage(Salvia officinalis L.)and thyme(Thymus vulgaris L.)measured by the oil stability index metbod[J].J Agric Food Chem,2002,50(7):1845.
- [18]Chen X,Ding J,Ye Y M.et al.Bioactive abietane and secoabietane dierpenoids from Salvia prionitis[J].J Nat Prod,2002,65(7):1016.
- [19]Chang J,Xu J,Li M.et al.Novel cytotoxie secoabietane rearranged diterpenoids from Salvia prionitis[J].Planta Med,2005,71(9):861.
- [20]王潮临.丹参对外周血中性粒细胞和单核细胞的调整作用[J].广西医科大学学报,1997,14(3):9.
- [21]薛明,汉卿,史彦斌,等.鼠尾草二萜醌及其衍生物的抗菌构效关系研究[J].中国农业科学,2000,33(3):88.
- [22]Jiang H L,Wang X Z,Xiao J,et al.New abietane diterpenoids from the roots of Salvia przewalskii[J].Tetrahedron,2013,69(32):6687.
- [23]Don M J,Shen C C,Syu W J,et al.Cytotoxic and aromatic constituents from Salvia miltiorrhiza[J].Phytochemistry,2006,67(5):497.
- [24]Ikeshiro Y,Hashimoto I,Iwamoto Y,et al.Diterpenoids from Salvia miltiorrhiza[J].Phytochemistry,1991,30(8):2791.
- [25]杨立新,李杏翠,刘超,等.甘西鼠尾草中化学成分研究[J].药学学报,2011,46(7):818.
- [26]M G AI-Hazimi H,A Miana G,M S H Deep.Terpenoids from Salvia lanigera[J].Phytochemistry,1987,26(4):1091.
- [27]Xu G,Peng L Y,Zhao Y,et al.Two new icetexane diterpenoids from Salvia przewalskii[J].Chem Pharm Bull,2005,53(12):1575.
- [28]Zhang B B,He B Q,Sun J B,et al.Diterpenoids from Saliva plebeia R.Br.and their antioxidant and anti-inflammatory activities[J].Molecules,2015,20(8):14879.
- [29]Ulubelen A,Miski M,Mabry T J.A new diterpene acid from Salvia tomentosa[J].J Nat Prod,1981,44(1):119.
- [30]Pan Z H,Li Y,Wu X D,et al.Norditerpenoids from Salvia castanea Diels f.pubescens[J].Fitoterapia,2012,83(6):1072.
- [31]Pan Z H,Wang Y Y,Li M M,et al.Terpenoids from Salviatrijuga[J].J Nat Prod,2010,73(6):1146.
- [32]曲贵武,岳喜典,安凤山,等.绒毛鼠尾草化学成分的研究[J].中国中药杂志,2012,37(13):1985.
- [33]王洪庆,杨立新,陈晓燕,等.甘西鼠尾草根化学成分研究[J].中药材,2015,38(6):1197.
- [34]Lin F W,G.Damu A,Wu T S.New abietane diterpene alkaloids possessing an oxazole ring from Salvia trijuga[J].Heterocycles,2006,68(1):159.
- [35]Pan Z H,Cheng J T,He J,et al.Splendidins A-C,three new clerodane diterpenoids from Salvia splendens[J].Helv Chim Acta,2011,94(3):417.
- [36]Pan Z H,He J,Li Y,et al.Castanolide and epi-castanolide,two novel diterpenoids with a unique seco-norabietane skeleton from Salvia castanea Diels f.pubescens Stib.[J].Tetrahedron Lett,2010,51(38):5083.
- [37]Xu G,Peng L Y,Tu L,et al.Three new diterpenoids from Salvia przewalskii Maxim[J].Helv Chim Acta,2009,92(2):409.
- [38]Xu G,Hou A J,Wang R R,et al.Przewalskin A:a new C23terpenoid with a 6/6/7 carbon ring skeleton from Salvia przewalskii Maxim[J].Org Lett,2006,8(20):4453.
- [39]Kawazoe K,Yamamoto M,Takaishi Y,et al.Rearranged abietane-type diterpenes from Salvia dichroantha[J].Phytochemistry,1999,50(3):493.
- [40]朱路平,向城,庄文婷,等.甘西鼠尾草化学成分研究[J].天然产物研究与开发,2013,25:785.
- [41]Nagy G,Günther G,MáthéI,et al.Diterpenoids from Salvia glutinosa,S.austriaca,S.tomentosa and S.verticillata roots[J].Phytochemstry,1999,52(6):1105.
- [42]Gu L W,Weng X C.Antioxidant activity and components of Salvia plebeia R.Br.—a Chinese herb[J].Food Chem,2001,73(3):299.
- [43]杨阳,吴志军,杨颖博,等.甘西鼠尾草中三个新的萜类化合物[J].高等学校化学学报,2011,32(6):1318.
- [44]Xue Y,Wu Y,Zhu H,et al.Salviprzols A and B,C21-and C22-terpenoids from the roots of Salvia przewalskii Maxim[J].Fitoterapia,2014,99:204.
- [45]Ohsaki A,Kawamata S,Ozawa M,et al.Salviskinone A,a diterpene with a new skeleton from Salvia przewalskii[J].Tetrahedron Lett,2011,52:1375.
- [46]Lu X Z,Luo H W,Niwa M.Trijuganone A and B:two new phenanthrenequinones from roots of Salvia trijuga[J].Planta Med,1990,56(1):87.
- [47]亢文佳,富艳彬,李达翃,等.荔枝草的化学成分研究[J].中草药,2015,46(11):1589.
- [48]Garcia-Alvarez M,Hasan M,Michavila A,et al.Epoxysalviacoccina,neo-clerodane diterpenoid from Salvia plebeian[J].Phytochemistry,1985,25(1):272.
- [49]Xu G,Yang X W,Wu C Y,et al.Przewalskone:a cytotoxic adduct of a danshenol type terpenoid and an icetexane diterpenoid via hetero-Diels-Alder reaction from Salvia przewalskii[J].Chem Commun,2012,48:4438.
- [50]Pan Z H,He J,Li Y,et al.Castanolide and epi-castanolide,two novel diterpenoids with a uniqueseconorabietane skeleton from Salvia castanea Diels f.pubescens Stib[J].Tetrahedron Lett,2010,51(38):5083.
- [51]Xu G,Hou A J,Zheng Y T,et al.Przewalskin B,a novel diterpenoid with an unprecedented skeleton from Salvia przewalskii Maxim[J].Org Lett,2007,9(2):291.
- [52]Zheng H B,Zhang T,Row K H,et al.Tricuspone,a rearranged diterpenoid from Salvia tricuspis[J].Bull Korean Chem Soc,2012,33(4):1360.
- [53]Farimania M M,Moghaddamb F M,Esmaeili M A,et al.A lupane triterpenoid and other constituents of Salvia eremophila[J].Nat Prod Res,2012,26(21):2045.
- [54]刘勇,宋雷,把文娟,等.粘毛鼠尾草三萜类化学成分的研究[J].华西药学杂志,2014,9(6):642.
- [55]Jiang T F,Lv Z H,Wang Y H,et al.On-line concentration by field-enhanced sample injection with reverse migrating micelles in micellar electrokinetic capillary chromatography for the analysis of triterpenoids from traditional Chinese medicine[J].Anal Chem,2010,65(9):945.
- [56]刘慧清,王国凯,林彬彬,等.荔枝草全草乙醇提取物的化学成分分析[J].植物资源与环境学报,2013,22(2):111.
- [57]鲁学照,罗厚蔚.三叶鼠尾草的化学研究[J].中国中药杂志,1996,21(7):424.
- [58]孙启文,吴松,柳航,等.荔枝草的化学成分及药理作用研究新进展[J].中国药师,2014,17(3):481.
- [59]Wang N,Niwa M,Luo H W.Triterpenoids from Salvia przewalskii[J].Phytochemistry,1988,27(1):299.
- [60]刘丽,戴轶群,谢国勇,等.荔枝草根的化学成分研究[J].中国药学杂志,2014,49(16):1393.
- [61]Weng X C,Wang W.Antioxidant activity of compounds isolated from Salvia plebeian[J].Food Chem,2000,71(4):489.
- [62]Moharrama F A,Marzouk M S,El-Shenawy S M,et al.Polyphenolic profile and biological activity of Salvia splendens leaves[J].J Pharm Pharmacol,2012,64:1678.
- [63]李佑生,马字澄,王文健.丹酚酸的心血管系统药理作用研究进展[J].中西医结合心脑血管病杂志,2006,4(9):791.
- [64]Jin M R,Xu H,Duan C H,et al.Two new flavones from Salvia plebeian[J].Nat Prod Res,2015,29(14):1315.
- [65]Weng X,Wang W.Antioxidant activity of compounds isolated from Salvia plebeian[J].Food Chem,2000,71(4):489.
- [66]Ren D B,Qin Y H,Yun Y H,et al.Separation of nine compounds from Salvia plebeia R.Br.using two-step high-speed counter-current chromatography with different elution modes[J].J Sep Sci,2014,37(16):2118.
- [67]Ulubelen A,Miski M,Mabry T J.Further flavones and triterpenes and the new 6-hydroxyluteolin 5-β-D-glucoside from Salvia tomentosa[J].J Nat Prod,1981,44(5):586.
- [68]Ulubelen A,Miski M,Neuman P,et al.Flavonoids of Salvia tomentosa(Labiatae)[J].J Nat Prod,1979,42(3):261.
- [69]Jin X F,Lu Y H,Wei D Z,et al.Chemical fingerprint and quantitative analysis of Salvia plebeia R.Br.by high-performance liquid chromatography[J].J Pharm Biomed Anal,2008,48(1):100.
- [70]Nugroho A,Kim M Y,Choi J,et al.In vivo sedative and gastroprotective activities of Salvia plebeian extract and its composition of polyphenols[J].Arch Pharm Res Vol,2012,35(8):1403.
- [71]Plattner R D,Powell R G.A secoisolariciresinol branched fatty diester from Salvia plebeia seed[J].Phytochemistry,1978,17(1):149.
- [72]Wu Y B,Ni Z Y,Shi Q W,et al.Constituents from Salvia species and their biological activities[J].Chem Rev,2012,112(11):5967.
- [73]Liu C Y,Jin Y H,Yu H S,et al.Preparation of przewalskinic acid A from salvianolic acid B using a crude enzyme from an Aspergillus oryzae strain[J].J Ind Microbiol Biotechnol,2014,41:887.
- [74]Lu X Z,Xu W H,Naoki H.Anthraquinones from Salvia przewalskii[J].Phytochemistry,1992,31(2):708.
- [75]Li B,Zhang C L,Peng L,et al.Comparison of essential oil composition and phenolic acid content ofselected Salvia species measured by GC-MS and HPLC methods[J].Ind Crop Prod,2015,69:329.
- [76]白楠.川滇产多种鼠尾草数属植物质量品质评价研究[D].成都:四川大学,2007.
- [77]中国科学院西北高原生物研究所.藏药志[M].西宁:青海人民出版社,1991:93.
- [78]蔡丽萍,吴翠玲,伍广甜.西藏地区“林芝丹参”的研究进展[J].广东药学院学报,2007,23(3):352.
- [79]叶华谷,廖文波,李辉,等.“林芝丹参”资源调查[J].中药材,2004,27(11):809.
- [80]Yang D F,Ma P D,Liang X,et al.Metabolic profiles and c DNA-AFLP analysis of Salvia miltiorrhiza and Salvia castanea Diel f.tomentosa Stib[J].PLo S ONE,2012,7(1):1.
- [81]古练权,卜宪章,马林.用于治疗高血氨症及肝性脑病的含二氢呋喃环结构的丹参酮类化合物:中国,1210025C[P].2005-07-13.
- [82]古练权,卜宪章,李贵华,等.用于预防和延缓早期老年痴呆症的隐丹参酮:中国,1210024C[P].2005-07-13.