周方方,徐朝霞,阿地拉·艾皮热,李金耀
ZHOU Fang-fang,XU Zhao-xia,ADILA Aipire,LI Jin-yao

• 1:新疆生物资源基因工程重点实验室新疆大学生命科学与技术学院
• 2:乌鲁木齐市第二十三中学

摘要(Abstract)：

哮喘是由多种免疫细胞参与的慢性呼吸道炎症疾病,常常导致气促、胸闷、咳嗽以及反复发作的喘息等症状,往往出现气流阻塞,影响人体健康。中草药(CHM)用于治疗哮喘已经有上千年的历史,大量研究表明中草药能有效的调节细胞免疫反应减缓哮喘症状。该文综述了近几年来中草药对免疫细胞的调节作用及相关分子机制的研究,包括炎症细胞数量、树突状细胞成熟、辅助性T细胞亚型之间的平衡、调节性T细胞的诱导及胞内信号通路,并展望了未来的研究方向。
Asthma is a kind of chronic respiratory inflammation,commonly with breathlessness,chest tightness,coughing,recurrent episodes of wheezing and airflow obstruction,severely affecting human health. A variety of immunocytes are involved in this chronic disease. Chinese herbal medicine( CHM) has a long history in the treatment of asthma. A large number of studies have shown that CHM could ameliorate asthma symptoms through regulating cellular immune responses. This paper reviewed the studies of CHM on the regulation of immunocytes and their mechanisms in recent years,including the count of inflammatory cells,maturation of dendritic cells,balance of helper T cell subtypes,induction of regulatory T cells and intracellular signaling pathways. We also proposed the future research directions about the effects of CHM on asthma treatment.

关键词(KeyWords)： 哮喘;中草药;炎症;免疫调节;信号通路
asthma;Chinese herbal medicine;inflammation;immunomodulation;signaling pathway

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金项目(31460241)

作者(Author): 周方方,徐朝霞,阿地拉·艾皮热,李金耀
ZHOU Fang-fang,XU Zhao-xia,ADILA Aipire,LI Jin-yao

DOI: 10.19540/j.cnki.cjcmm.20170907.006

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