程玥,丁泽贤,张越,姜悦航,王雷,罗建平,彭代银,俞年军,陈卫东
CHENG Yue,DING Ze-xian,ZHANG Yue,JIANG Yue-hang,WANG Lei,LUO Jian-ping,PENG Dai-yin,YU Nian-jun,CHEN Wei-dong

• 1:安徽中医药大学药学院
• 2:中药复方安徽省重点实验室
• 3:中药饮片制造新技术与研发安徽省重点实验室
• 4:安徽省中医药科学院药物制剂研究所

摘要(Abstract)：

茯苓为国家药食同源中药材品种,具有利水渗湿、健脾宁心等功效。茯苓多糖作为其中最主要的活性物质之一,药理研究表明其具有调节机体免疫力、抗炎、抗氧化、抗肿瘤、保肝等药理活性,存在巨大的开发利用价值。该文通过查阅相关文献,系统总结茯苓多糖及其衍生物的化学结构及近年来对其药理作用的研究进展,全面深入探讨茯苓多糖的化学组成和活性,讨论当前存在问题,为深入探究茯苓多糖构效关系以及进一步开发利用提供参考。
Poria cocos is a both medicinal and edible Chinese herb variety, with the effects of diuretic, spleen-enhancing and tranquilizing. P. cocos polysaccharide(PCP) is one of the most important active substances of P. cocos. Pharmacological research shows that PCP has a variety of pharmacological activities such as regulating immunity, anti-inflammatory, anti-oxidation, antitumor, and liver protection, with a huge development and utilization value. By consulting the relevant literature, we systematically summarized the chemical structures and the research progress on pharmacological activities of PCP and its derivatives in recent years to explore the chemical compositions and activities of PCP thoroughly. In addition, the current problems were discussed in this article to provide reference for further exploration of the structure-activity relationship of PCP and its further development and utilization.

关键词(KeyWords)： 茯苓多糖;化学结构;结构修饰;药理活性
Poria cocos polysaccharides;chemical structure;structure modification;pharmacological activities

Abstract:

Keywords:

基金项目(Foundation): 国家重点研发计划项目(2017YFC1701600,2017YFC1701601,2017YFC1701602,2017YFC1701603,2017YFC1701605);; 安徽省科技重大专项项目(18030801131);; 安徽省中央引导地方科技发展专项(201907d07050002)

作者(Author): 程玥,丁泽贤,张越,姜悦航,王雷,罗建平,彭代银,俞年军,陈卫东
CHENG Yue,DING Ze-xian,ZHANG Yue,JIANG Yue-hang,WANG Lei,LUO Jian-ping,PENG Dai-yin,YU Nian-jun,CHEN Wei-dong

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