马晓晶,杨健,马桂荣,曾雯,郭娟,马莹
MA Xiao-jing,YANG Jian,MA Gui-rong,ZENG Wen,GUO Juan,MA Ying

• 1:中国中医科学院中药资源中心道地药材国家重点实验室培育基地
• 2:北京中医药大学东直门医院

摘要(Abstract)：

中药现代化是中医药的重要发展方向，从基础研究着手对中药进行深入探索，对了解中药及其活性成分的作用机制及中药制剂开发利用具有重要意义。丹参是我国常用的大宗中药材之一，临床上被广泛应用于心脑血管疾病的预防和治疗，其研究广受国内外关注。随着化学分析仪器和测序技术的不断升级、网络药理学和合成生物学技术的飞速发展，多种现代化研究手段被应用于丹参的相关研究中。学者们分别利用化学成分分析手段系统研究了丹参的主要活性成分、利用现代化药理学研究手段探究了丹参药效活性成分的作用机制、利用组学分析及分子生药学手段研究了活性成分合成调控机制及合成生物学应用等，并对丹参临床制剂展开了应用研究。该文系统地总结了丹参及其活性成分相关的现代化研究进展，重点介绍了丹参活性成分的药理作用、制剂研究、生物合成及调控机制研究，相关研究的现代化技术手段和研究思路具有一定的普适性，期望能够进一步发挥丹参在中药研究中的模式作用。
Modernization of Chinese medicine is an important development direction of traditional Chinese medical sciences. It is of great significance to understand the mechanism of Chinese medicine with basic research, which can also accelerate the development and utilization of Chinese medicine. Salviae Miltiorrhizae Radix et Rhizoma is one of the most commonly used Chinese medicines in China for the prevention and treatment of cardiovascular and cerebrovascular diseases. It has received key and extensive attention worldwide in the following aspects: main active ingredients and their pharmacological mechanism, function and regulation of their biosynthetic pathway and application of their synthetic biology as well as the clinical preparations. The new and developing chemical analysis, network pharmacology, molecular pharmacognosy and omics make the modernization research of Salviae Miltiorrhizae Radix et Rhizoma comprehensive and in-depth. This study systematically reviewed the modernization research of Salviae Miltiorrhizae Radix et Rhizoma, which focused on its pharmacological effects, preparation research, biosynthesis and regulation mechanism of the active ingredients, and expected to exert the model role of Salviae Miltiorrhizae Radix et Rhizoma in the research of Chinese medicine.

关键词(KeyWords)： 丹参;合成生物学;丹参基因组;丹参酮;丹酚酸
Salviae Miltiorrhizae Radix et Rhizoma;synthetic biology;Salvia miltiorrhiza genome;tanshinones;salvianolic acids

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金项目(82003904,31961133007,82011530137);; 国家重点研发计划项目(2020YFA0908000);; 财政部中央本级重大增减支项目(2060302);; 中国中医科学院科技创新工程项目(CI2021A04110)

作者(Author): 马晓晶,杨健,马桂荣,曾雯,郭娟,马莹
MA Xiao-jing,YANG Jian,MA Gui-rong,ZENG Wen,GUO Juan,MA Ying

DOI: 10.19540/j.cnki.cjcmm.20220808.101

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