王晓琴,黄慧,李彩峰,李旻辉
WANG Xiao-qin,HUANG Hui,LI Cai-feng,LI Min-hui

• 1:内蒙古医科大学药学院
• 2:内蒙古自治区中医药研究所

摘要(Abstract)：

列当属、肉苁蓉属和草苁蓉属在植物分类学上均归类为列当科。这3个属的物种药用植物亲缘关系相近,传统疗效相似。苯乙醇苷类成分作为代表性的化合物,无论是在含量上,还是在化学结构多样性方面均占有一定优势,它们被认为是这几个属的重要药效物质基础。该文单列叙述了苯乙醇苷类化合物及其药理活性;此外,为了更好地比较属间药效物质基础的差异,也逐一综述了其他化合物。这些研究结果对有效开发、合理利用列当科药用植物资源具有重要的参考价值。
The genus Orobanche, Cistanche and Boschniakia are taxonomically classified as members of Orobanchaceae. The medicinal plants of these three genera are closely related, and their traditional curative effects are similar. As representative compounds, phenethyl glycosides are predominantly dominant type both in amount and in chemical structural varieties, which are considered to be the important bioactive material basis of these genera. In this paper, phenethyl glycosides and their pharmacological activities are described in a single list. In addition, the other compounds were also reviewed in order to better compare the difference of the bioactive substances. These findings have important reference value for effective development and rational utilization of resources of medicinal plants in the family Orobanchaceae.

关键词(KeyWords)： 药用植物亲缘学;列当属;肉苁蓉属;草苁蓉属;苯乙醇苷类成分;药理活性
pharmaphylogeny;Orobanche;Cistanche;Boschniakia;phenylethanoid glycosides;pharmacological activities

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金项目(81260615);; 内蒙古医科大学校级科研创新团队项目(YKD2017KJCXTD013)

作者(Author): 王晓琴,黄慧,李彩峰,李旻辉
WANG Xiao-qin,HUANG Hui,LI Cai-feng,LI Min-hui

DOI: 10.19540/j.cnki.cjcmm.20180912.002

参考文献(References)：

• [1] 中国科学院中国植物志编辑委员会.中国植物志.第69卷 [M]. 北京:科学出版社,1990.
• [2] 马毓泉. 内蒙古植物志.第4卷 [M]. 呼和浩特:内蒙古人民出版社,1993:345.
• [3] 白贞芳, 刘勇, 王晓琴. 列当属、肉苁蓉属和草苁蓉属植物传统药物学调查[J]. 中国中药杂志, 2014, 39(23):4548.
• [4] 宋志宏, 雷丽, 屠鹏飞. 肉苁蓉属植物的药理活性研究进展[J]. 中草药, 2003, 34(9):113.
• [5] 李彩峰, 王晓琴, 刘勇, 等. 草苁蓉化学成分及药理活性研究进展[J]. 中草药, 2014, 45(7):1016.
• [6] 颜芳, 曾光尧, 谭健兵, 等. 植物中苯乙醇苷类化合物研究进展[J]. 中南药学,2013,11(5):358.
• [7] 郑晓珂, 刘媛媛, 冯卫生, 等. 天然苯乙醇苷类化合物研究进展[J]. 中国新药杂志,2011,20(3):230.
• [8] Andary C, Wylde R, Laffite C, et al. Structures of verbascoside and orobanchoside, caffeic acid sugar esters from Orobanche rapum Gensitae[J]. Phytochemistry, 1982, 21(5):1123.
• [9] Viron C, Lhermite S, André P, et al. Isolation of phenylpropanoid glycosides from Orobanche rapum by high speed countercurrent chromatography[J]. Phytochem Anal, 2015, 9(1):39.
• [10] Qu Z Y, Zhang Y W, Yao C L,et al. Chemical constituents from Orobanche cernua Loefling[J]. Biochem Syst Ecol, 2015, 60:199.
• [11] Afifi M S, Lahloub M F, Elkhayaat S A, et al. Crenatoside: a novel phenylpropanoid glycoside from Orobanche crenata[J]. Planta Med, 1993, 59(4):359.
• [12] Lin L C, Chiou W F, Chou C J. Phenylpropanoid glycosides from Orobanche caerulescens[J]. Planta Med, 2004, 70(1):50.
• [13] 曲正义,金银萍,张玉伟,等.列当属药用植物化学成分、生物活性及临床应用研究进展[J].中国实验方剂学杂志,2018,24(1):209.
• [14] Zhao J, Yan M, Huang Y, et al. Study on water-soluble constituents of Orobanche coerulescens[J]. Nat Prod Res Dev, 2009, 21:619.
• [15] 赵军,闫明,黄毅,等.紫花列当化学成分的研究[J].中药材,2007, 30(10):1255.
• [16] 韩继新, 杨九艳, 邵红霞, 等. 蒙药黄花列当化学成分的研究[J]. 内蒙古大学学报:自然科学版,2010,41(6):669.
• [17] 杨美珍, 王晓琴, 李超. 弯管列当的化学成分研究[J]. 中草药, 2014, 45(17):2447.
• [18] Lahloub M F, Zaghloul A M, elKhayaat S A, et al. 2′-O-acetylpoliumoside: a new phenylpropanoid glycoside from Orobanche ramosa[J]. Planta Med, 1991, 57(5):481.
• [19] 王李俊, 杨琴,王飞, 等. 列当中1个新的苯乙醇苷化合物[J]. 中草药, 2016,47(8):1269.
• [20] 张蔷蓉. 列当中1个新的苯乙醇苷类化合物[J]. 中国中药杂志, 2017, 42(6):1136.
• [21] Tetsuya M, Yuko Y, Akira K, et al. A novel phenylethanoid, isocrenatoside isolated from the whole plant of Orobanche coerulescens[J]. Nat Med, 1998, 52:455.
• [22] 南泽东, 赵明波, 姜勇, 等. 塔中栽培荒漠肉苁蓉化学成分研究[J]. 中国中药杂志,2013,38(16):2665.
• [23] 刘晓明, 姜勇, 孙永强, 等. 肉苁蓉化学成分研究[J]. 中国药学杂志,2011,46(14):1053.
• [24] 杨建华, 堵年生, 热娜·卡斯木. 人工栽培盐生肉苁蓉的苯乙醇苷类化学成分[J]. 中国药学,2005,14(4):242.
• [25] 徐朝晖, 杨峻山, 吕瑞绵, 等. 肉苁蓉化学成分的研究[J]. 中草药,1999,30(4):244.
• [26] 徐文豪, 邱声祥, 赵继红, 等. 肉苁蓉化学成分的研究[J]. 中草药,1994,25(10):509.
• [27] 堵年生, 王泓, 易杨华. 肉苁蓉中苯乙醇甙类成分的分离和鉴定[J]. 天然产物研究与开发,1993,5(4):5.
• [28] 堵年生, 周丕文, 王健, 等. 管花肉苁蓉化学成分的研究[J]. 中国药科大学学报,1993,24(1):46.
• [29] Morikawa T, Pan Y, Ninomiya K, et al. Acylated phenylethanoid oligoglycosides with hepatoprotective activity from the desert plant Cistanche tubulosa[J]. Bioorgan Med Chem, 2010, 18(5):1882.
• [30] Xiong Q, Kadota S, Tani T, et al. Antioxidative effects of phenylethanoids from Cistanche deserticola [J]. Biol Pharma Bull, 1996, 19(12):1580.
• [31] Tu P F, Song Z H, Shi H M, et al. Arylethyl (=phenylethanoid) glycosides and oligosaccharide from the stem of Cistanche tubulosa[J]. Helv Chim Acta,2010, 89(5):927.
• [32] Pan Y N, Morikawa T, Ninomiya K, et al. Bioactive constituents from chinese natural medicines. ⅩⅩⅩⅪ. Four new acylated phenylethanoid oligoglycosides, kankanosides J1, J2, K1, and K2, from stems of Cistanche tubulosa[J]. Chem Pharm Bull, 2010, 41(37):575.
• [33] Deyama T, Yahikozawa K, Aleasa H S, et al. Constituents of plants growing in qatar:part ⅩⅩⅧ. Constituents of Cistanche phelypaea[J]. Qatar Univ Sci J,1995,15(1): 51.
• [34] 张杰,赵天翼,李鸿钰,等. 管花肉苁蓉提取物中化学成分研究[J]. 海峡药学,2016,10(28):39.
• [35] Kobayashi H, Kobaya S, Karaasawa H, et al. Studies on the constituents of Cistanchis Herba V:isolation and structures of two new phenylpropanoid glycosides, cistanosides E and cistanosides F[J]. Chem Pharm Bull,1985,33(4):1452.
• [36] Yoshikawa M, Matsuda H, Morikawa T, et al. Phenylethanoid oligoglycosides and acylated oligosugars with vasorelaxant activity from Cistanche tubulosa[J]. Bioorgan Med Chem, 2006, 14(22):7468.
• [37] Jiang Y, Li S P, Wang Y T, et al. Differentiation of Herba Cistanchis by fingerprint with high-performance liquid chromatography-diode array detection-mass spectrometry[J]. J Chromatogr A, 2009, 1216(11):2156.
• [38] Lei L, Jiang Y, Liu X, et al. New glycosides from Cistanche salsa[J]. Helv Chim Acta, 2010, 90(1):79.
• [39] Nan Z D, Zeng K W, Shi S P, et al. Phenylethanoid glycosides with anti-inflammatory activities from the stems of Cistanche deserticola cultured in Tarim desert[J]. Fitoterapia, 2013, 89(1):167.
• [40] Hayashi K. Studies on the constituents of Cistanchis Herba[J]. Shoyakugaku Zasshi,2004,58(6):307.
• [41] 雷丽, 宋志宏, 屠鹏飞, 等. 盐生肉苁蓉化学成分的研究[J].中草药, 2003, 34(4):293.
• [42] Liu X M, Li J, Jiang Y, et al. Chemical constituents from Cistanche sinensis (Orobanchaceae)[J]. Biochem Syst Ecol, 2013, 47(8):21.
• [43] Yoshizawa F, Deyama T, Takizawa N, et al. The constituents of Cistanche tubulosa (SCHRENK) HOOK. f. Ⅱ. Isolation and structures of a new phenylethanoid glycoside and a new neolignan glycoside[J]. Chem Pharm Bull, 1990, 38(7):1927.
• [44] Karasawa H, Kobayashi H, Takizawa N, et al. Studies on the constituents of Cistanchis Herba.Ⅶ.Isolation and structures of cistanosides H and I[J].Planta Med,1991,57(5):481.
• [45] Kobayashi H, Oguchi H, Takizawa N, et al. New phenylethanoid glycosides from Cistanche tubulosa (Schrenk) Hook. f. I.(pharmacognosy,chemical)[J]. Chem Pharm Bull, 1987, 35(8):3309.
• [46] Tu P F, Shi H M, Song Z H, et al. Chemical constituents of Cistanche sinensis[J]. J Asian Nat Prod Res, 2007, 9(1):79.
• [47] Kobayashi H,Karasawa H,Miyase T,et al.Studies on the constituents of Cistanchis Herba. Ⅳ:isolation and structures of two new phenylpropanoid glycosides,cistanosides C and cistanosides D[J].Chem Pharm Bull,1984,32(10):3880.
• [48] Karasawa H, Kobayashi H, Takizawa N, et al. Studies on the constituents of Cistanchis Herba. Ⅷ: isolation and structure of a new phenylethanoid glycoside, cistanoside G[J]. Shoyakugaku Zasshi, 1986, 40(8):721.
• [49] Nan Z D, Zhao M B, Zeng K W, et al. Anti-inflammatory iridoids from the stems of Cistanche deserticola cultured in Tarim desert[J]. Chin J Nat Medicines, 2016, 14(1):61.
• [50] 屠鹏飞, 何燕萍, 楼之岑. 栽培肉苁蓉的化学成分研究[J]. 天然产物研究与开发, 1997,2(9):7.
• [51] Bougandoura A, D′Abrosca B, Ameddah S, et al. Chemical constituents and in vitro anti-inflammatory activity of Cistanche violacea Desf.(Orobanchaceae)extract[J]. Fitoterapia, 2016, 109:248.
• [52] 杨建华, 胡君萍, 热娜·卡斯木,等. 人工栽培盐生肉苁蓉环烯醚萜苷类成分的研究[J]. 时珍国医国药, 2009, 20(3):522.
• [53] 宋志宏, 莫少红, 陈燕,等. 管花肉苁蓉化学成分的研究[J]. 中国中药杂志, 2000, 25(12):728.
• [54] 屠鹏飞, 何燕萍. 肉苁蓉鲜花序的化学成分研究[J]. 中草药, 1994,25(9):451.
• [55] Xie H, Morikawa T, Matsuda H, et al. Monoterpene constituents from Cistanche tubulosachemical structures of kankanosides A-E and kankanol[J]. Chem Pharm Bull,2006, 54(44):669.
• [56] Toshio M, Pan Y, Kiyofumi N, et al. Iridoid and acyclic monoterpene glycosides, kankanosides L, M, N, O, and P from Cistanche tubulosa[J]. Chem Pharm Bull, 2010, 58(10):1403.
• [57] Lei L, Yang F, Zhang T, et al. Preparative isolation and purification of acteoside and 2′-acetyl acteoside from Cistanches salsa (C.A. Mey.) G. Beck by high-speed counter-current chromatography[J]. J Chromatogr A, 2001, 912(1):181.
• [58] 南泽东, 赵明波, 姜勇,等. 塔中栽培荒漠肉苁蓉中的木脂素类成分[J]. 中国中药杂志, 2015, 40(3):463.
• [59] 薛德钧. 管花肉苁蓉化学成分研究[J]. 中国中药杂志, 1997, 22(3):170.
• [60] Kobayashi H, Karasawa H, Miyase T, et al. Studies on the constituents of Cistanchis Herba. Ⅵ. Isolation and structure of a new iridoid glycoside, 6-deoxycatalpol[J]. Chem Pharm Bull, 2008, 33(9):3645.
• [61] 陈妙华, 刘凤山, 许建萍. 补肾壮阳中药肉苁蓉的化学成分研究[J]. 中国中药杂志, 1993, 18(7):424.
• [62] Yamaguchi K, Shinohara C, Kojima S, et al. (2E,6R)-8-hydroxy-2,6-dimethyl-2-octenoic acid, a novel anti-osteoporotic monoterpene, isolated from Cistanche salsa[J].Biosci Biotech Bioch, 1999, 63(4):731.
• [63] Konishi T, Shoji J. Studies on the constituents of Boschniakia rossica Fedtsch. et Flerov. Ⅰ. Isolation and structures of new phenylpropanoid glycosides, rossicasides B, C and D[J]. Chem Pharm Bull, 2008, 29(10):2807.
• [64] Lin L C, Chen K T. New phenylpropanoid glycoside from Boschniakia rossica[J]. Chin Pharm J, 2004, 56(2):77.
• [65] Shyr M H, Tsai T H, Lin L C. Rossicasins A, B and rosicaside F, three new phenylpropanoid glycosides from Boschniakia rossica[J]. Chem Pharm Bull, 2006, 54(2):252.
• [66] Zhang Y, Wu C, Guo L, et al. Triglyceride accumulation inhibitory effects of phenylpropanoid glycosides from Boschniakia rossica Fedtsch et Flerov[J]. Fitoterapia, 2013, 85(1):69.
• [67] 吴春华, 王涛, 山口能宏, 等. 草苁蓉苷A-E 的分离与结构鉴定 [J]. 辽宁中医药大学学报, 2013, 15(7):55.
• [68] 刘晓明, 屠鹏飞. 荒漠肉苁蓉的化学成分研究[C]. 和田:第三届肉苁蓉暨沙生药用植物学术研讨会, 2007.
• [69] Konishi T, Narumi Y, Watanabe K, et al. Comparative studies on the constituents of a parasitic plant and its host. Ⅲ: on the constituents of Boschniakia rossica [J]. Chem Pharm Bull, 1987, 35(10): 4155.
• [70] Wu C H, Wang T, Yamaguchi Y, et al. A newphenylpropanol glycoside and its five known analogues from Boschniakia rossica [J]. Chin Herb Med, 2013, 5(1):5.
• [71] Yin Z Z, Kim H S, Kim Y H, et al. Iridoid compounds from Boschniakia rossica [J]. Arch Pharm Res, 1999,22(1):78.
• [72] 易以军, 曹正中, 吴厚铭, 等. 草苁蓉化学成分的研究[J]. 药学学报, 1999, 34(9): 686.
• [73] 桂明玉, 张宏桂, 金永日, 等. 草苁蓉化学成分的研究[J]. 中国中药杂志, 1997, 32(4): 204.
• [74] Murai F, Tagawa M. 8-Epi-iridodial glucoside from Boschniakia rossica [J]. Planta Med, 1982, 46(1):45.
• [75] Yim S H, Kim H J, Liu Y Z, et al. A novel iridoid from Boschniakia rossica [J]. Chem Pharm Bull, 2004, 52(2):289.
• [76] Murai F, Tagawa M. The absolute configuration of boschnaloside and the chemical conversion of genipin into boschnaloside [J]. Chem Pharm Bull, 1980, 28(6):1730.
• [77] 吴春华, 李春梅, 陈凤,等. 草苁蓉 2 个单萜苷类化合物的NMR 研究 [J]. 波谱学杂志, 2013, 30(2):247.
• [78] 杨建华,胡君萍,热娜·卡斯木,等. 肉苁蓉属植物中六种苯乙醇苷类化合物抗氧化活性的构效关系研究[J].中药材,2009,32(7):1067.
• [79] 曲正义,侯微,金银萍,等.向日葵列当抗氧化活性研究[J]. 中药材, 2010, 33(11):1780.
• [80] 李丽,时东方,桂语歌,等.肉苁蓉中苯乙醇苷化合物的抗氧化活性研究[J]. 安徽农业科学, 2009, 37(32):15835.
• [81] 刘洋,修效友,汪维云.响应面分析法优化肉苁蓉苯乙醇苷提取反应及其抗氧化反应研究[J]. 安徽农业大学学报, 2015, 42(2):294.
• [82] 吴海虹,玄国东,刘春泉,等.肉苁蓉苯乙醇苷的纯化及其抗氧化活性研究[J]. 食品科学, 2008, 29(6):190.
• [83] 玄国东,刘春泉.肉苁蓉苯乙醇苷对D-半乳糖致衰老模型小鼠的抗衰老作用研究[J]. 中药材, 2008, 31(9):1385.
• [84] Chen W, Lin H R, Wei C M, et al. Echinacoside, a phenylethanoid glycoside from Cistanche deserticola,extends lifespan of Caenorhabditis elegans and protects from Aβ-induced toxicity[J]. Biogerontology, 2018,19(1):47.
• [85] Zhang D, Lu C T, Yu Z, et al. Echinacoside alleviates UVB irradiation-mediated skin damage via inhibition of oxidative stress, DNA damage, and apoptosis[J]. Oxid Med Cell Longev, 2017(3):1.
• [86] 骆新,李建英,许永华,等.肉苁蓉苯乙醇苷对大鼠高原脑水肿的防治作用[J]. 中南药学, 2014, 20(8):747.
• [87] 陶义存,李建英,许永华,等.肉苁蓉苯乙醇苷对大鼠高原肺水肿的防治作用[J].中国实验方剂学杂志,2014,20(15):134.
• [88] 陶义存, 董翔, 许永华,等. 肉苁蓉苯乙醇总苷对高原脑水肿大鼠水通道蛋白4的影响[J]. 中国现代中药, 2015, 17(4):302.
• [89] 曾克武,廖理曦,万彦军,等.基于靶点“钩钓”策略的肉苁蓉苯乙醇苷药理靶点鉴定及功效解析[J]. 中草药, 2018,49(1):173.
• [90] Lin L C, Wang Y H, Hou Y C, et al. The inhibitory effect of phenylpropanoid glycosides and iridoid glucosides on free radical production and beta2 integrin expression in human leucocytes[J]. J Pharm Pharmacol, 2006, 58(1):129.
• [91] 邢晓旭,刘钟杰,韩博.麦角甾苷及松果菊苷对体外培养大鼠成骨细胞BMP2基因表达的影响[J]. 动物医学进展, 2011, 32(8): 45.
• [92] Xu X, Zhang Z, Wang W, et al. Therapeutic effect of cistanoside A on bone metabolism of ovariectomized mice [J]. Molecules, 2017, 22(2):197.
• [93] Tian S, Miao M, Bai M, et al. Phenylethanoid glycosides of cistanche on menopausal syndrome model in mice[J]. Saudi Pharm J, 2017, 25(4):537.
• [94] 李刚.肉苁蓉苯乙醇苷促智作用实验研究[J].内蒙古医学院学报,2011,33(2):141.
• [95] 刘美虹,赵国君,陈哲.肉苁蓉苯乙醇苷对东莨菪碱致记忆障碍小鼠保护作用的研究[J].包头医学院学报,2011,27(6):9.
• [96] 居博伟,杨建华,闫瑶,等.肉苁蓉苯乙醇总苷对Aβ1-42诱导的PC12细胞损伤的保护作用[J]. 新疆医科大学学报, 2017, 40(5):634.
• [97] Zhang Y J, Long H Y, Zhou F Q, et al. Echinacoside′s nigrostriatal dopaminergic protection against 6-OHDA-induced endoplasmic reticulum stress through reducing the accumulation of Seipin[J].J Cell Mol Med, 2017,21(12):3761.
• [98] Pieretti S, Giannuario A D, Capasso A, et al. Pharmacological effects of phenylpropanoid glycosides from Orobanche hederae[J]. Phytother Res, 1992, 6(2):89.
• [99] 邓敏,赵金垣,屠鹏飞,等.松果菊苷对TNFα诱导的SH-SY5Y细胞凋亡的保护作用[J]. 中国药理学通报, 2005, 21(2):169.
• [100] 齐晓岚,肖海涛,肖雁,等.松果菊苷及异麦角甾苷对神经细胞尼古丁受体表达的影响[J]. 时珍国医国药, 2011, 22(7):1561.
• [101] 王玉娟,刘向,习瑶,等.繁殖实验评价肉苁蓉提取物苯乙醇苷类对衰老大鼠生殖能力的影响[J].医学研究与教育,2016,33(1):1.
• [102] 赵东海,张磊,张艳,等.肉苁蓉苯乙醇苷对环磷酰胺致小鼠生精障碍的治疗作用及其机制[J].吉林大学学报:医学版,2014,40(3):612.
• [103] 梁华伦,江秀娟,黎奔,等.基于拉曼光谱技术的肉苁蓉苯乙醇苷对氧化损伤人精子DNA的保护作用[J].广州中医药大学学报,2015,32(1):121.
• [104] 李刚,朱文斌,牛飞,等.肉苁蓉苯乙醇苷对大鼠精子体外氧化损伤的保护作用研究[J]. 时珍国医国药, 2010, 21(9):2205.
• [105] 由淑萍,赵军,木克热木·吐地买提,等.肉苁蓉苯乙醇苷类成分对BSA诱导的肝纤维化大鼠转化生长因子β1表达的影响[J]. 癌变·畸变·突变, 2015, 27(6):409.
• [106] 木克热木·吐地买提,由淑萍,赵军,等.肉苁蓉苯乙醇苷类成分对BSA致大鼠肝纤维化影响的实验研究[J]. 新疆医科大学学报, 2015,38(5):567.
• [107] 由淑萍,赵军,马龙,等.肉苁蓉苯乙醇总苷及其单体对肝星状细胞增殖和凋亡的影响[J]. 癌变·畸变·突变, 2017, 29(1):13.
• [108] Ahn J, Chae H S, Chin Y W, et al. Dereplication-guided isolation of new phenylpropanoid-substituted diglycosides from Cistanche salsa and their inhibitory activity on NO production in macrophage[J]. Molecules, 2017, 22(7):1138.
• [109] Quan J S, Yin X, Xu H. Boschniakia rossica, prevents the carbon tetrachloride-induced hepatotoxicity in rat[J]. Exp Toxicol Pathol, 2011, 63(1/2):53.
• [110] Quan J S, Piao L, Wang X, et al. Rossicaside B protects against carbon tetrachloride-induced hepatotoxicity in mice[J].Basic Clin Pharmacol, 2009, 105(6):380.
• [111] 王毓杰,康云雪.管花肉苁蓉苯乙醇苷提取物对血管内皮细胞EA.hy926增殖的抑制和凋亡的诱导作用[J].华西药学杂志,2016,31(6):569.
• [112] 金延华,刘春彦,金爱花,等.草苁蓉苯丙素苷对肺癌细胞周期分布和凋亡的影响[J]. 中国实验方剂学杂志, 2011, 17(7):213.
• [113] 靳春丽,毛新民,李琳琳, 等.肉苁蓉苯乙醇苷对高原肺动脉高压大鼠肺血流动力学的影响[J].中国实验方剂学杂志,2014,20(12):197.
• [114] El-Shabrawy O A, Melek F R, Ibrahim M, et al. Pharmacological evaluation of the glycosidated phenylpropanoids containing fraction from Orobanche crenata[J]. Arch Pharm Res, 1989, 12(1):22.
• [115] Capasso A, Pieretti S, Giannuario A D, et al. Pharmacological study of phenylpropanoid glycosides: platelet aggregation and blood pressure studies in rabbits and rats[J]. Phytother Res, 2010, 7(1):81.
• [126] 白贞芳,陆景坤,王晓琴,等.弯管列当提取物的抗氧化活性[J].中国实验方剂学杂志,2012,18(18):232.