王诗恒,刘剑锋,章轶立,董臻
WANG Shi-heng,LIU Jian-feng,ZHANG Yi-li,DONG Zhen

• 1:中国中医科学院中国医史文献研究所
• 2:北京中医药大学

摘要(Abstract)：

评价连花清瘟胶囊治疗病毒性感冒的有效性和安全性,以期指导临床用药。系统检索CNKI全文数据库,万方数据平台,维普数据库,SinoMed医学文献数据库和PubMed医学期刊数据库,搜索连花清瘟胶囊治疗病毒性感冒的随机对照实验(RCTs),对符合纳入标准的文献用Cochrane协作网提供的标准评价文献质量,并用RevMan 5.3软件进行Meta分析。共纳入8篇文献,总样本量为955例,试验组478例,对照组477例。疗效方面,连花清瘟胶囊组优于对照组,总有效率RR=1.20,95%CI[1.09,1.32],P=0.70;体温复常率RR=1.13,95%CI[1.02,1.24],P=0.001;症状改善率RR=1.18,95%CI[1.12,1.24],P=0.16。不良反应方面,对照组优于连花清瘟胶囊组,不良反应发生率RR=1.54,95%CI[0.73,3.24],P=0.93。连花清瘟胶囊治疗病毒性感冒疗效比较好,但不良反应发生率高,其安全性须引起重视。鉴于纳入文献数量较少,质量偏低,其有效性和安全性尚需更多高质量的临床研究去证实。
To evaluate the efficacy and safety of Lianhua Qingwen Capsules in the treatment of viral influenza in order to guide clinical medication. Randomized controlled trials(RCTs) regarding Lianhua Qingwen Capsules for treatment of viral influenza were searched in the CNKI, WanFang, VIP, SinoMed and PubMed. The quality of papers selected based on the inclusion criteria were assessed according to the Cochrane collaboration method and Meta-analysis was performed by using RevMan 5.3 software. A total of 8 articles were included, with a total sample size of 955 cases, including 478 cases in the treatment group, and 477 cases in the control group. In terms of the therapeutic effect, Lianhua Qingwen Capsules group was superior to the control group, with a total effective rate RR=1.20, 95%CI [1.09,1.32], P=0.70; recovery rate of body temperature RR=1.13, 95%CI [1.02,1.24], P=0.001; rate of symptom improvement RR=1.18, 95%CI [1.12,1.24], P=0.16. In terms of adverse reactions, the control group was superior to Lianhua Qingwen Capsules, with the incidence of adverse reactions RR=1.54, 95%CI [0.73,3.24], P=0.93. Lianhua Qingwen Capsules has a better therapeutic effect on viral influenza, but the incidence of adverse reactions is high, and its safety must be taken seriously. Given the small number of documents included and the low quality, the efficacy and safety of Lianhua Qingwen Capsules shall be confirmed by more high-quality clinical studies.

关键词(KeyWords)： 连花清瘟胶囊;病毒性感冒;系统评价;Meta分析
Lianhua Qingwen Capsules;viral influenza;systematic review;Meta-analysis

Abstract:

Keywords:

基金项目(Foundation): 中国中医科学院自主选题(zz100511)

作者(Author): 王诗恒,刘剑锋,章轶立,董臻
WANG Shi-heng,LIU Jian-feng,ZHANG Yi-li,DONG Zhen

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