银翘散抗流感病毒有效部位群化学成分的分离与鉴定Isolation and Elucidation of Chemical Constituents with Antiviral Action from Yinqiaosan on Influenza Virus
石钺,石任兵,刘斌,陆蕴如,杜力军
SHI Yue 1; SHI Ren-bing 2; LIU Bin 2; LU Yun-ru 2; DU Li-jun 1 (1.School of Life Sciences and Engineering;
摘要(Abstract)：
目的 :对银翘散抗流感病毒作用的物质基础进行研究。方法 :运用色谱技术进行分离 ,波谱等方法鉴定化合物的结构。结果 :从银翘散抗流感病毒有效部位群中分离得到 11种成分 ,鉴定为牛蒡子苷 (Ⅰ )、连翘苷(Ⅱ )、连翘酯苷 (Ⅲ )、甘草苷 (Ⅳ )、甘草素 (Ⅴ )、染料木素 (Ⅵ )、芒柄花素 (Ⅶ )、大豆素 (Ⅷ )、6 甲氧基大豆素 (Ⅸ )、3,3′ ,4 三甲氧基鞣花酸 (Ⅹ )和绿原酸 (Ⅺ )。结论 :染料木素、大豆素、6 甲氧基大豆素和 3,3′,4 三甲氧基鞣花酸为首次从银翘散群药中获得。
Objective: To study the chemical constituents with antiviral action from Yinqiaosan on influenza virus. Method: Constituents were isolated by different kinds of column chromatography and their structures were elucidated with chemical and spectral methods. Result: Eleven chemical constituents were isolated and elucidated as arctiin,phillyrin,forsythiaside,liquiritigenin,liquiritin,genistein,formononetin,daidzein,glycitrin,3,3′,4-tri-omethlellagic acid and chlorogenic acid. Conclusion: Genistein,daidzein,glycitrin and 3,3′,4-tri-omethlellagic acid were isolated from Yinqiaosan for the first time.
关键词(KeyWords)：
银翘散;抗流感病毒;化学成分
Yinqiaosan;anti-influenza virus;chemical constituents
基金项目(Foundation): 国家中医药管理局重点课题 ( 972 0 72 )
作者(Authors):
石钺,石任兵,刘斌,陆蕴如,杜力军
SHI Yue 1; SHI Ren-bing 2; LIU Bin 2; LU Yun-ru 2; DU Li-jun 1 (1.School of Life Sciences and Engineering;
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