王优杰,施晓虹,李佳璇,洪燕龙,吴飞,赵立杰,冯怡
WANG You-jie,SHI Xiao-hong,LI Jia-xuan,HONG Yan-long,WU Fei,ZHAO Li-jie,FENG Yi

• 1:上海中医药大学创新中药研究院中药现代制剂技术教育部工程研究中心
• 2:上海中医药大学上海中医健康服务协同创新中心

摘要(Abstract)：

设计一套可测定黏附力的新装置,并利用此装置对中药提取液进行喷雾干燥热熔黏壁预测研究。该装置以物性测定仪为基础测试平台,添加一套提供热风的设备,并配上摄像头,温湿度探头等搭建而成,可以模拟喷雾干燥仪的干燥环境,分析药液的黏附性随干燥进程的变化。采用数据挖掘机器,建立预测喷雾干燥热熔型黏壁的模型并进行验证,结果显示该装置可以通过物料的黏附力预测喷雾干燥热熔型黏壁。研究还发现热熔型黏壁的物料黏附性随水分的蒸发而逐渐变大,不黏壁的物料的黏附力则是先变大后急速下降。
A new device was designed to measure adhesive force and predict whether traditional Chinese medicine extracts would appear hot-melt sticking in spray drying process.Based on the physical property tester as fundamental test platform,the device was fixed with a camera,a temperature and humidity sensor probe and a set of equipment for hot air.This device could simulate the dry environment of spray dryer and analyze the variables of testing solutions' adhesiveness against drying time.To establish and validate a model of predicting hot-melt sticking in spray drying,data was collected by using data mining. The results of this study proved that the device could be used to predict the hot-melt sticking in spray drying based on the adhesive force of materials(testing solutions).In addition,the study also found that the adhesiveness of the hot-melt sticking materials gradually increased with the evaporation of water,while that of non-sticking materials first increased and then rapidly decreased.

关键词(KeyWords)： 喷雾干燥;热熔型黏壁;物性测试仪;黏附力
spray drying;hot-melt sticking;physical tester;adhesive force

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金项目(81503263);; 上海市科学技术委员会项目(16401902300);; 上海市卫计委中医药科技创新项目(ZYKC201603003)

作者(Author): 王优杰,施晓虹,李佳璇,洪燕龙,吴飞,赵立杰,冯怡
WANG You-jie,SHI Xiao-hong,LI Jia-xuan,HONG Yan-long,WU Fei,ZHAO Li-jie,FENG Yi

DOI: 10.19540/j.cnki.cjcmm.20181105.007

参考文献(References)：

• [1] 李伟锋,刘海峰,龚欣.工程流体力学[M].2版.上海:华东理工大学出版社,2016:6.
• [2] Wang Y J,Xie Y L,Xu D S,et al.Hydroxypropyl methylcellulose reduces particle adhesion and improves recovery of herbal extracts during spray drying of Chinese herbal medicines[J].Dry Technol, 2014,32:557.
• [3] 王优杰.中药喷雾干燥粘壁机理及抗粘壁技术研究[D].上海:上海中医药大学,2013.
• [4] 王优杰,冯怡,杨胤,等.辅料对改善强力宁提取液喷雾干燥粘壁现象的作用研究[J].中成药,2012,34(1):34.
• [5] 李佳璇,施晓虹,赵立杰,等.中药提取液化学成分与喷雾干燥黏壁现象的相关性研究[J].中国中药杂志,2018,43(19):3867.
• [6] 罗晓健,刘慧,梁红波,等.中药浸膏粉的玻璃化转变及其应用[J].中国中药杂志,2017,42(1):192.
• [7] 钱坤, 匡琪, 董伟,等.苦黄颗粒制剂工艺研究[J].中药材,2008,31(2):291.
• [8] 王志良,单金海, 张宇,等.玻璃化转变对中药喷雾干燥过程和产品质量的影响[C].石家庄:2008年中国药学会学术年会暨第八届中国药师周,2008.
• [9] Adhikaria B, Howesa T, Bhandari B R, et al.In situ characterization of stickiness of sugar-rich foods using a linear actuator driven stickiness testing device[J].J Food Eng,2003,58:11.
• [10] 王优杰,谢亚林,冯怡,等.基于星点设计-效应面优化法的玄麦甘桔方提取液喷雾干燥工艺参数优化[J].中国新药杂志,2013,22(12):1385.
• [11] Rahman S.Food properties handbook[M]. Boca Raton:CRC Press,1995.
• [12] 王优杰,徐德生,冯怡,等.利用数值模拟技术分析中药喷雾干燥黏壁原因[C].南宁:2013年中国药学大会暨第十三届中国药师周,2013.
• [13] 刘慧, 罗晓健, 何雁,等.不同DE值麦芽糊精对五味子喷雾干燥粉性质的影响[J].中国中药杂志,2016,41(16):3016.