张翼冠,谭蕊蓉,任思冲,马欣,严志祥,华桦,鄢良春,戴瑛,赵军宁
ZHANG Yi-guan,TAN Rui-rong,REN Si-chong,MA Xin,YAN Zhi-xiang,HUA Hua,YAN Liang-chun,DAI Ying,ZHAO Jun-ning

• 1:四川省中医药转化医学中心四川省中医药科学院转化药理研究所国家中医药管理局中药质量生物评价重点研究室四川省道地药材系统开发工程技术研究中心中药品质评价与创新中药研究四川省重点实验室

摘要(Abstract)：

中医证候客观化与中药复方药效学评价标准一直是中医中药基础研究难以突破的关键环节。现代免疫学认为,机体是一个平衡体,免疫失衡是百病之源。中医诊治疾病的思维方式也是"平衡",认为生病是因为人体"偏性",即"阴阳、表里、寒热、虚实"等失衡所致。整合医学催生了广义免疫组学,免疫功能(免疫平衡)系统评价已是整合医学诊疗模式的重要依据,而平衡也是中医整体观核心思想。由此,可以预见,广义免疫组学整体或局部组织平衡原理为中医整体观与现代整合医学桥接理论基础之一,是中医症候客观化研究与中药复方药效评价的重要依据之一。由此,笔者根据动态、整体精准医学模式背景,根据新病因观,提出运用信息学、统计学方法构建基于广义免疫组学整体与局部组织平衡原理的中医证候客观化与中药复方评价体系。该体系将会深入揭示中医整体观理论科学内涵,为中药复方药效评价提供新思路新方法,亦可作为亚健康人群免疫力筛查,为中医分子治未病学科发展提供理论支持等。随着临床样本量与数据量不断积累,该评价体系将更精准、更智能。
For the basic research on the traditional Chinese medicine( TCM),objective syndrome of traditional Chinese medicine and evaluation criteria of traditional Chinese medicine compounds are hardly to break though. While,the modern immunology points out that the body is a counterbalance state and immune imbalance is the root of sickness. The thinking mode of treating diseases in traditional Chinese medicine is also " balance",considering disease is the result of bias which present the imbalance of " Yin counters Yang", " exterior counters interior", " cold counters heat" and " weak counters strong". The Chinese herbal compound formula preparation was applied on disease therapy based on theory of Chinese medicine,which was confirmed by long period clinical application. It is composed of multi-compounds and has the characteristic of multi-targeting. Integrative medicine has spawned pan-immunomics,and the evaluation of immune function( immune balance) has become an important basis for diagnosis and treatment models of integrative medicine. In addition,balance is the core idea of whole-systemic conception of traditional Chinese medicine. Therefore,we speculate that immune balance under pan-immunomic can bridge the traditional Chinese medicine and modern integrative medicine and is the important basis for objective syndrome of traditional Chinese medicine and evaluation criteria of traditional Chinese medicine compounds. According to the bridging theory,we attempt to utilize informatics and statistical methods to construct an evaluation system for pharmacodynamics of traditional Chinese medicine based on its moderate regulation and the balanced adjustment of immunity under pan-immunomic,which further reveal the scientific essence of the whole-systemic view of traditional Chinese medicine. This research brings out a new valuable strategy and provides a theoretical basis for accelerating the transformation of traditional Chinese medicine,especially the exploitation of Chinese herbal compound formula,and constructing the new drug innovation and review system for traditional Chinese medicine. Besides as a reference for traditional Chinese medicine objective syndrome and pharmacodynamics of traditional Chinese medicine compounds,the evaluation system can screen the immunity of sub-health population also. With the continuous accumulation of clinical sample and data,the evaluation system will be more accurate and intelligent.

关键词(KeyWords)： 广义免疫组;新病因观;中西医整体观桥接依据;中药复方适度调节原理;中医证候;中药复方
pan-immunomics;new concept of illness;integrated Chinese and Western medicines;moderation-tegrated-balance presupposition;traditional Chinese medicine syndrome;Chinese herbal compound

Abstract:

Keywords:

基金项目(Foundation): 国家重点基础研究发展计划(973)项目(2009CB522801);; 国家“重大新药创制”科技重大专项(2011ZX09401-304,2015ZX09501004-001-005);; 国家自然科学基金面上项目(30672651,81073047,81470180);; 四川省中医药管理局项目(20017Z001)

作者(Author): 张翼冠,谭蕊蓉,任思冲,马欣,严志祥,华桦,鄢良春,戴瑛,赵军宁
ZHANG Yi-guan,TAN Rui-rong,REN Si-chong,MA Xin,YAN Zhi-xiang,HUA Hua,YAN Liang-chun,DAI Ying,ZHAO Jun-ning

DOI: 10.19540/j.cnki.cjcmm.20180629.002

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