苏瑾,周荣荣,郭非非,周勤文,许海玉
SU Jin,ZHOU Rong-rong,GUO Fei-fei,ZHOU Qin-wen,XU Hai-yu

• 1:中国中医科学院中药研究所
• 2:山西中医药大学基础医学院
• 3:南京同仁堂药业有限责任公司

摘要(Abstract)：

该文对舒冠颗粒配伍应用的中医理论进行分析,并对其6种植物药何首乌、丹参、黄精、川芎、淫羊藿、红花进行网络药理学分析,借助整合药理学平台获取化学成分及药物作用靶点,通过ETCM数据库搜集适应症靶标。对舒冠颗粒的配伍、成分、作用靶标、通路进行分析,确定其可能的最优适应症。结果表明,舒冠颗粒治疗中医症候为胸痹,君药为丹参。网络药理学分析发现舒冠颗粒药物靶标富集结果与适应症冠心病、心绞痛以及动脉粥样硬化均相关,结合适应症靶标进一步分析,心绞痛可能为舒冠颗粒的最优适应症。舒冠颗粒中的229种成分,共涉及核心靶标109个,其中直接作用心绞痛疾病靶标2个(TNF和MMP9)。此外舒冠颗粒亦可通过MAPK,NFKB,GF等靶标间接干预心绞痛病程。涉及的心绞痛相关的主要通路为PI3K-Akt信号通路、RAS信号通路、TNF信号通路、雌激素信号通路以及糖异生信号通路,可干预心绞痛的多个环节如炎症反应、血脂代谢血管扩张等。
The paper analyzed the combined administration of traditional Chinese medicine Shuguan Granules, and studied its six plant herbs, namely Polygoni Multiflori Radix, Salviae Miltiorrhizae Radix et Rhizoma, Polygonati Rhizoma, Chuanxiong Rhizoma, Epomedii Folium, and Carthami Flos by network pharmacology analysis, in order to define chemical constituents and drugs targets through integrated pharmacology platform. Based on the results, indications of Shuguan Granules were collected through the ETCM database. Therefore, the present study could determine the potential optimal indications of the drug. The results showed that chest apoplexy was the main traditional Chinese medicine(TCM) symptom treated by Shuguan Granules, whose monarch drug was Salviae Miltiorrhizae Radix et Rhizoma. Network pharmacology analysis found that the target enrichment results of Shuguan Granules were related to the indications of coronary heart disease, angina and atherosclerosis. According to the indications, angina may be the best indication for Shuguan Granules. The 229 components in Shuguan Granules involved a total of 109 core targets, of which TNF and MMP9 were the direct targets to the angina disease. In addition, Shuguan Granules could also indirectly intervene in the progression of angina through MAPK, NFKB, GF and other targets. The main pathways involving angina pectoris are PI3 K-Akt signaling pathway, RAS signaling pathway, TNF signaling pathway, Estrogen signaling pathway and glycolysis/gluconeogenesis, which can intervene in many aspects of angina, such as inflammatory reaction, blood lipid metabolism and vasodilation.

关键词(KeyWords)： 舒冠颗粒;心绞痛;整合药理学;分子网络
Shuguan Granules;angina;integrative pharmacology;molecular network

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金面上项目(81673700,81774201);国家自然科学基金重点项目(81830111);; 国家重点基础研究发展计划(973)项目(2015CB554406)

作者(Author): 苏瑾,周荣荣,郭非非,周勤文,许海玉
SU Jin,ZHOU Rong-rong,GUO Fei-fei,ZHOU Qin-wen,XU Hai-yu

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